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Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut

Leticia Tordesillas1, Adeeb H Rahman2, Boris M Hartmann3

  • 1Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY; Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

The Journal of Allergy and Clinical Immunology
|August 18, 2016
PubMed
Abstract

No abstract available in PubMed .

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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