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Updated: Mar 16, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Refractory Arterial Insufficiency Associated with Janus Kinase 2 Positive Essential Thrombocythaemia
Yogeesan Sivakumaran1, Anthony Freeman2
1Department of Surgery, Bankstown-Lidcombe Hospital, Sydney, NSW, Australia.
Abstract:
Essential thrombocythaemia (ET) is one of the severe rare clonal haematologic stem cell disorders that encompass myeloproliferative neoplasms. ET has a well-described association with peripheral arterial thrombosis, which presents a challenging clinical presentation. Further understanding into the underlying pathophysiology of thrombosis in ET has been made following the identification of the Janus Kinase 2 (JAK2) mutation, which is thought to confer a prothrombotic phenotype. Here we present a case of refractory arterial insufficiency associated with JAK2-positive ET.
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