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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
[Asteatotic eczema as paraneoplastic syndrome]
N Koks1, Y J Assen, E J Libourel
1Franciscus Gasthuis & Vlietland, locatie Gasthuis, Rotterdam.
Background:
Asteatotic eczema is rarely associated with an underlying malignancy. The condition as paraneoplastic syndrome is characterised by glucocorticoid resistance.
Case Description:
A 66-year old woman came to the emergency room with symptoms of dehydration resulting from diarrhoea due to cyclosporine therapy for treatment-resistant eczema. CT scan of thorax and abdomen showed multiple, pathologically enlarged lymph nodes. Histological examination of a lymph node biopsy from the right axilla showed an ALK-negative, anaplastic large T-cell lymphoma.
Conclusion:
Asteatotic eczema is usually innocuous but may also be linked to malignancy. A careful physical examination and early referral to second-line care are needed for rapid diagnosis and treatment of the underlying condition.
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