Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Population Genetics?01:25

What is Population Genetics?

65.4K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.4K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

77.2K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
77.2K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

65.6K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
65.6K
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

895
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
895
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

383
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
383
Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial.

Trials·2009
Same author

Long-term assessment of bladder and bowel dysfunction after radical hysterectomy.

Gynecologic oncology·2009
Same author

Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells.

Toxicology in vitro : an international journal published in association with BIBRA·2009
Same author

A rapid and simple method for identifying Mycobacterium tuberculosis W-Beijing strains based on detection of a unique mutation in Rv0927c by PCR-SSCP.

Microbes and infection·2009
Same author

CO oxidation over AuPd(100) from ultrahigh vacuum to near-atmospheric pressures: the critical role of contiguous Pd atoms.

Journal of the American Chemical Society·2009
Same author

Daunorubicin-loaded magnetic nanoparticles of Fe(3)O(4) greatly enhance the responses of multidrug-resistant K562 leukemic cells in a nude mouse xenograft model to chemotherapy.

Zhongguo shi yan xue ye xue za zhi·2009
Same journal

Construction and implementation of an ICF-based integrated teaching model for genetic disease severity assessment.

Yi chuan = Hereditas·2026
Same journal

Identification and prenatal genetic testing of pathogenic variants in a case of myoclonus-dystonia syndrome.

Yi chuan = Hereditas·2026
Same journal

A novel strategy to enhance precise targeting of the RNA base editor mxABE.

Yi chuan = Hereditas·2026
Same journal

Functional study of the soybean rapid alkalinization factor <i>GmRALF34s</i> in response to saline-alkali stress.

Yi chuan = Hereditas·2026
Same journal

Role of <i>broad</i> in intestinal stem cells of adult <i>Drosophila</i>.

Yi chuan = Hereditas·2026
Same journal

The p53 R267W mutation intervenes p21-mediated cell cycle arrest and promotes proliferation and migration of lung cancer cells.

Yi chuan = Hereditas·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling
20:36

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Published on: July 4, 2007

9.3K

Application of computer simulators in population genetics.

Feng Gao1, Hai-peng Li2

  • 11. CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai 200031, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China;

Yi Chuan = Hereditas
|August 18, 2016
PubMed
Summary
This summary is machine-generated.

Computer simulators are essential for studying genome-wide DNA polymorphism patterns and evolutionary dynamics. This review compares 32 simulators, aiding researchers in selecting appropriate tools for population genetics research.

More Related Videos

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling
20:36

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Published on: July 4, 2007

9.3K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K

Area of Science:

  • Population Genetics
  • Computational Biology
  • Genomics

Background:

  • Next-generation sequencing technologies have accelerated genome sequencing.
  • Computer simulators are vital for analyzing genome-wide DNA polymorphism patterns.
  • Both forward-time and backward-time simulations offer complementary approaches for evolutionary studies.

Purpose of the Study:

  • To review the theoretical framework of population genetics.
  • To compare 32 computer simulators published in the last decade.
  • To discuss future directions in simulator development.

Main Methods:

  • Literature review of population genetics theory.
  • Comparative analysis of 32 DNA polymorphism simulators.
  • Discussion of simulation methodologies (forward-time vs. backward-time).

Main Results:

  • Identified 32 relevant computer simulators for population genetics.
  • Detailed comparison of simulator features, capabilities, and applications.
  • Highlighted the strengths and weaknesses of various simulation approaches.

Conclusions:

  • Computer simulators are indispensable tools for population genetics research.
  • The choice of simulator depends on specific research needs, such as evolutionary dynamics or parameter estimation.
  • Advancements in sequencing necessitate the continued development of sophisticated simulation tools.