Recent Advances in Gold-Catalyzed Intermolecular Aryl C-H Functionalization
1Center for Interdisciplinary Nanoscience (iNANO), Department of Chemistry, Aarhus University, Gustav Wieds vej 14, 8000, Aarhus C, Denmark. kramer@chem.au.dk.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 18, 2016
Summary
Gold catalysis enables direct and selective C-H bond functionalization for greener chemical synthesis. This review highlights recent advances in gold-catalyzed aryl C-H functionalization, offering shorter synthetic routes to valuable compounds.
Area of Science:
- Organic Chemistry
- Catalysis
- Green Chemistry
Background:
- Direct C-H bond functionalization offers efficient synthetic pathways.
- Gold catalysis shows promise for selective arene decoration.
- Oxidative gold catalysis has emerged as a key strategy in recent years.
Approach:
- This Minireview critically examines transformations and mechanistic data in intermolecular C-H functionalization of arenes using homogeneous gold catalysis.
- Focuses on advancements within the last five years.
- Aims to encourage further research in this area.
Key Points:
- Gold catalysis facilitates regioselective functionalization of aryl C-H bonds.
- Oxidative gold catalysis provides a general strategy for C-H functionalization.
- Mechanistic understanding of these reactions is improving.
Conclusions:
- Gold catalysis is a powerful tool for greener and shorter synthesis of valuable chemicals.
- Further research into intermolecular C-H functionalization with gold catalysis is warranted.
- This review consolidates current knowledge to facilitate future discoveries.
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