[Development of Regulatory T Cells Mediated by NF-κB and Its Role in GVHD -Review]

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Updated: Mar 16, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
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Hai-Ying Zhang1, Qiang Zhao1, Tao Wu2

  • 1Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|August 18, 2016
PubMed

Graft versus host disease (GVHD) is the major complication of allogenic hematopoietic stem cell transplantation (allo-HSCT), and is a mainly responsible result for the non-recurrence-related mortality of long-term survived patient after transplantation. Studies indicated that regulatory T (Treg) cells can inhibit early-GVHD. Since the transcriptional factor NF-κB has been implicated in the regulation of Treg cell proliferation and activation, it becomes a potential target of GVHD therapy. Thus, in this review the function and signaling pathway of NF-κB, as well as the relationship between GVHD and NF-κB, are discussed and summarized.

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