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Updated: Mar 16, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy
Chanchala D Kaddi1, May D Wang2
1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.
Abstract:
We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination effects of cooperation and drug treatment qualitatively match experimental observations from the literature.
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