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Related Experiment Videos

Autonomic neuropathy in BB rats and alterations in bladder function.

M Paro1, M Prosdocimi, W X Zhang

  • 1Fidia Research Laboratories, Abano Terme, Italy.

Diabetes
|August 1, 1989
PubMed
Summary

Diabetic urinary bladder dysfunction stems from nerve damage. Early changes in sensory nerves of the micturition reflex arc precede bladder control problems in diabetes.

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Area of Science:

  • Urology
  • Neuroscience
  • Diabetology

Background:

  • Diabetic complications can affect multiple organ systems.
  • Urinary bladder dysfunction is a common, yet often overlooked, complication in diabetes.
  • The micturition reflex involves a complex interplay of neural pathways.

Purpose of the Study:

  • To investigate in vivo urinary bladder function in diabetic rats.
  • To correlate bladder dysfunction with morphometric changes in key nerves of the micturition reflex arc.
  • To elucidate the initial site of neural damage in diabetic bladder dysfunction.

Main Methods:

  • BB rats were studied at 4 and 6 months of diabetes.
  • In vivo bladder function was assessed after controlled distension.

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  • Morphometric analysis of pelvic and hypogastric nerves was performed.

    • Main Results:

    • Diabetic bladders exhibited irregular contractions with reduced frequency and increased amplitude.
    • Abnormal micturition occurred at elevated threshold volumes in diabetic rats.
    • Progressive axonopathy of sensory fibers and atrophy of efferent fibers were observed.

    Conclusions:

    • Diabetic urinary bladder dysfunction is linked to nerve damage.
    • Sensory neuropathy, affecting the afferent limb of the micturition reflex, appears to initiate bladder dysfunction in diabetes.