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IgM Memory Cells: First Responders in Malaria

Sara L Stone1, Frances E Lund1

  • 1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Immunity
|August 18, 2016
PubMed

Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function as first responders by rapidly differentiating into T-cell-dependent plasmablasts and T-cell-independent plasma cells.

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