Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

773
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
773
Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

12.1K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
12.1K
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

15.0K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
15.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suppression of PANC-1 pancreatic cancer cell proliferation by gemcitabine and ultrasound-mediated microbubble therapy.

Nucleosides, nucleotides & nucleic acids·2026
Same author

Monitoring of Tissue Perfusion During Arterial Occlusion With Remote Photoplethysmographic Imaging.

Journal of biophotonics·2026
Same author

<i>In vitro</i>gold nanoparticle radiation sensitization effects in conjunction with a 2.5 megavoltage photon beam in MDA-MB-231, HeLa and PC-3 cell lines.

Biomedical physics & engineering express·2026
Same author

A computer vision method to evaluate tumor-infiltrating lymphocytes and multiparametric modeling of neoadjuvant systemic therapy response in breast cancer.

Therapeutic advances in medical oncology·2026
Same author

Influence of Arterial Occlusion at Various Cuff Positions on Systemic Circulation Measured by Remote Photoplethymography (rPPG).

Advances in experimental medicine and biology·2026
Same author

Evaluating the Effect of Drug Loading on the Acoustic Response of Nanobubbles in Stable and Inertial Cavitation Regimes.

IEEE open journal of ultrasonics, ferroelectrics, and frequency control·2025

Related Experiment Video

Updated: Mar 16, 2026

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
10:39

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Published on: March 4, 2015

15.9K

Microvascular contrast enhancement in optical coherence tomography using microbubbles.

Homa Assadi1, Valentin Demidov2, Raffi Karshafian3

  • 1Ryerson University, Department of Physics, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada.

Journal of Biomedical Optics
|August 18, 2016
PubMed
Summary

Gas microbubbles (MBs) enhance optical coherence tomography (OCT) imaging contrast and detect blood flow dynamics. This study shows MBs improve microvascular visualization, aiding hemodynamic investigations.

More Related Videos

Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

13.2K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
10:39

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Published on: March 4, 2015

15.9K
Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

13.2K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.4K

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Fluid Dynamics

Background:

  • Optical coherence tomography (OCT) is a non-invasive imaging technique.
  • Enhancing OCT contrast, especially in microvasculature, remains a challenge.
  • Gas microbubbles (MBs) show potential as intravascular contrast agents.

Purpose of the Study:

  • To investigate gas microbubbles (MBs) as intravascular contrast agents for optical coherence tomography (OCT).
  • To evaluate the impact of MBs on OCT image contrast and blood flow dynamics.
  • To assess the feasibility of MBs for microvasculature imaging and hemodynamic investigations.

Main Methods:

  • Fabrication of vascular phantoms with human blood and MB-blood mixtures.
  • Evaluation using swept-source structural and speckle variance (sv) OCT imaging.
  • Analysis of speckle decorrelation times under varying flow conditions.

Main Results:

  • MBs significantly increased structural and svOCT image contrast compared to blood alone.
  • Faster speckle decorrelation times were observed in the presence of MBs.
  • The contrast enhancement effect was most pronounced in svOCT mode and decreased with higher flow velocities.

Conclusions:

  • Gas microbubbles are feasible intravascular contrast agents for OCT.
  • MBs enhance microvascular contrast and aid in hemodynamic investigations.
  • MBs show promise for improving OCT angiography and microvasculature visualization.