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Iron deficiency in patients with heart failure
Sarah Fitzsimons1, Robert Neil Doughty1
1Department of Medicine and National Institute for Health Innovation, University of Auckland, and Greenlane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
European Heart Journal. Cardiovascular Pharmacotherapy
|August 18, 2016
Summary
Iron deficiency (ID) is common in heart failure (HF). Correcting ID improves exercise capacity and symptoms in HF patients, even without anemia.
Area of Science:
- Cardiology
- Internal Medicine
- Nutritional Science
Background:
- Iron deficiency (ID) is a frequent comorbidity in patients diagnosed with heart failure (HF).
- In healthy individuals without anemia, correcting iron deficiency can restore exercise capacity and endurance.
- Recent studies indicate potential benefits of iron replacement in heart failure patients.
Purpose of the Study:
- To review the clinical significance of iron deficiency in heart failure.
- To examine the evidence supporting iron replacement therapy in heart failure patients.
Main Methods:
- Literature review of existing studies on iron deficiency and heart failure.
- Analysis of clinical trials investigating iron replacement in heart failure with reduced ejection fraction.
Main Results:
- Iron deficiency is highly prevalent in heart failure patients.
- Iron replacement has demonstrated improvements in symptoms and exercise capacity in patients with heart failure with reduced ejection fraction.
- Benefits of iron correction are observed irrespective of the presence of anemia.
Conclusions:
- Iron deficiency is clinically relevant in heart failure.
- Iron replacement is a promising therapeutic strategy for improving outcomes in heart failure patients.
- Further research should explore optimal iron repletion strategies in heart failure.
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