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Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to

S García-Rodríguez1, S Arias-Santiago2, G Blasco-Morente2

  • 1Department of Cellular Biology and Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico de la Salud de Granada (PTS Granada), Av. Conocimiento, 17, Granada-18016, Spain.

Journal of the European Academy of Dermatology and Venereology : JEADV
|August 19, 2016
PubMed
Abstract

Insights

Psoriasis patients show elevated levels of specific microRNAs (miRNAs) in blood and cells, which correlate with disease severity. Treatment reduces these miRNA levels, indicating their role in psoriasis pathogenesis and potential as biomarkers.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • MicroRNAs (miRNAs) are key gene regulators implicated in various diseases.
  • Altered miRNA expression is observed in psoriasis, suggesting their involvement in the condition's development.

Purpose of the Study:

  • To investigate the expression of inflammation and toll-like receptor (TLR)-related miRNAs in psoriasis patients.
  • To analyze changes in miRNA levels in peripheral blood mononuclear cells (PBMCs) and plasma before and after treatment.

Main Methods:

  • Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to measure miRNA expression.
  • Expression levels were analyzed in treatment-naive psoriasis patients and matched controls.

Main Results:

  • Psoriasis patients exhibited increased baseline expression of specific miRNAs (miRNA-155, let-7i, miRNA-21, miRNA-146a, miRNA-223) in PBMCs and plasma.
  • miRNA-155 expression in PBMCs correlated with Psoriasis Area Severity Index (PASI).
  • Treatment led to reduced PASI scores and modulated miRNA expression, with miRNA-155 decreasing and plasma miRNAs (miRNA-21, miRNA-146a, miRNA-223) down-regulating.

Conclusions:

  • Elevated miRNA-155 in PBMCs is linked to psoriasis severity and decreases with treatment remission.
  • Specific miRNAs (miRNA-21, miRNA-146a, miRNA-223) in PBMCs and plasma are upregulated at baseline and modulated by treatment.
  • These findings highlight the distinct roles of TLR-related miRNAs in psoriasis pathogenesis.

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