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Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Self-assembling peptide-based building blocks in medical applications.

Handan Acar¹, Samanvaya Srivastava², Eun Ji Chung³

¹Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.

Advanced Drug Delivery Reviews

|August 19, 2016

Summary

Peptides and peptide-conjugates are versatile biomaterials forming self-assembled nanostructures for advanced medical applications. This review explores their design, assembly, and therapeutic potential in diagnostics, immune modulation, and regenerative medicine.

Keywords:

Medicine Peptide Peptide-conjugates Self-assembly Supramolecular

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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Area of Science:

Biomaterials Science
Nanotechnology
Medical Chemistry

Background:

Peptides and peptide-conjugates are emerging biomaterials with tunable properties.
Self-assembled peptide nanostructures offer precise selectivity and multifunctionality for clinical use.
Existing challenges in clinical applications can be addressed by advanced nanomaterial design.

Purpose of the Study:

To review recent advancements in peptide and peptide-conjugate-based nanomaterials for medical applications.
To categorize nanomaterial self-assembly based on driving forces: supramolecular peptide interactions and conjugate interactions.
To highlight in vivo studies in therapeutics, diagnostics, immune modulation, and regenerative medicine.

Main Methods:

Literature review of recent developments in peptide and peptide-conjugate nanomaterials.
Categorization of self-assembled nanostructures based on supramolecular interactions.
Analysis of in vivo studies focusing on therapeutic and diagnostic applications.

Main Results:

Nanostructures driven by peptide-peptide supramolecular interactions were discussed.
Nanostructures driven by conjugate-conjugate interactions were presented.
Emphasis on in vivo applications including therapeutics, diagnostics, immune modulation, and regenerative medicine.

Conclusions:

Peptide and peptide-conjugate nanostructures show significant promise for diverse medical applications.
Understanding self-assembly mechanisms is crucial for designing effective nanomaterials.
Further research into in vivo performance and clinical translation is warranted.