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Updated: Mar 16, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Platelet function testing in cardiac surgery
1Department of Anaesthesia and Critical Care, Liverpool Heart and Chest Hospital, Liverpool, UK. Seema.Agarwal@lhch.nhs.uk.
Insights
Point-of-care platelet function tests can assess platelet reactivity in patients undergoing cardiac surgery. This review examines devices and their impact on reducing blood loss and improving patient outcomes.
Area of Science:
- Cardiology
- Hematology
- Surgical Innovation
Background:
- Bleeding complications in cardiac surgery significantly increase morbidity and mortality.
- Increased anti-platelet medication use elevates the risk of bleeding in cardiac surgery patients due to platelet dysfunction.
- Individual variability in platelet inhibition necessitates precise monitoring.
Purpose of the Study:
- To review point-of-care platelet function testing devices used in cardiac surgery.
- To evaluate the evidence supporting the use of these devices in assessing platelet reactivity.
- To determine the effect of these devices on blood loss during cardiac surgery.
Main Methods:
- Literature review of studies on point-of-care platelet function testing devices.
- Analysis of evidence regarding device application in cardiac surgery settings.
- Examination of data correlating device use with patient blood loss.
Main Results:
- Several point-of-care devices are available for assessing platelet function.
- Evidence suggests these devices can measure individual platelet reactivity.
- The impact of these devices on reducing blood loss in cardiac surgery requires further investigation.
Conclusions:
- Point-of-care testing offers potential for personalized management of platelet function in cardiac surgery.
- Further research is needed to establish the clinical utility and cost-effectiveness of these devices in reducing blood loss.
- Optimizing platelet function monitoring may improve patient safety and outcomes in cardiac surgery.
Abstract:
Bleeding in cardiac surgery is known to cause increased morbidity and mortality. The rise in the use of anti-platelet medication has led to an increase in the number of patients presenting for cardiac surgery with platelet dysfunction, who are at a heightened risk of bleeding. However, the extent of platelet inhibition is well known to differ among individuals. In the past few years, a number of point-of-care platelet function testing devices, which may be able to assess platelet reactivity, have entered the market. This review will examine the devices most commonly studied and the evidence surrounding their use in cardiac surgery and their effect on blood loss.
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