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A Putative Multiple-Demand System in the Macaque Brain.

Daniel J Mitchell1, Andrew H Bell2, Mark J Buckley3

  • 1Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 7EF, United Kingdom, and Daniel.mitchell@mrc-cbu.cam.ac.uk.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 19, 2016
PubMed
Summary
This summary is machine-generated.

Researchers identified a macaque brain network similar to the human multiple-demand (MD) system using fMRI connectivity. This finding helps guide future studies on cognitive functions in nonhuman primates.

Keywords:
connectivityfMRIfrontoparietalmacaquemultiple demandresting state

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Primate Brain Imaging

Background:

  • The human brain utilizes a frontoparietal
  • multiple-demand
  • (MD) network for cognitively demanding tasks, suggesting a core role in goal-oriented behavior.
  • A homologous network in nonhuman primates is hypothesized but not yet described, hindering comparative cognitive studies.

Purpose of the Study:

  • To identify and delineate a macaque brain network analogous to the human multiple-demand (MD) system.
  • To leverage functional magnetic resonance imaging (fMRI) connectivity to map this network in rhesus macaques.
  • To provide a foundation for future electrophysiological and task-based fMRI research in nonhuman primates.

Main Methods:

  • Utilized fMRI connectivity analysis in 35 anesthetized rhesus macaques.
  • Mapped putative macaque MD regions based on human frontoparietal MD foci.
  • Employed an iterative cross-validation process to refine region definitions and maximize connectivity.
  • Conducted whole-brain connectivity analyses to identify robustly connected voxels.

Main Results:

  • Identified functionally connected putative macaque MD regions under anesthesia.
  • Revealed seven robustly connected clusters across frontoparietal, insular, and lateral fissure regions.
  • The delineated network shows strong similarity to the human MD system.

Conclusions:

  • Successfully identified a macaque counterpart to the human multiple-demand (MD) network using fMRI connectivity.
  • The proposed macaque MD regions serve as a valuable guide for future electrophysiological and task-based fMRI research.
  • This work facilitates comparative neuroscience research into the neural basis of cognition.