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Resilience in Aging Mice.

James L Kirkland1, Michael B Stout1, Felipe Sierra2

  • 1Mayo Clinic Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|August 19, 2016
PubMed
Summary
This summary is machine-generated.

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New interventions targeting aging mechanisms can extend lifespan and improve healthspan. Researchers explored using resilience testing in animal models as a way to measure aging and develop new treatments for age-related decline.

Area of Science:

  • Gerontology and aging research
  • Physiology and stress response
  • Translational medicine

Background:

  • Aging is linked to reduced resilience, increasing susceptibility to diseases and poor recovery from stress.
  • Interventions targeting aging mechanisms show promise in extending lifespan and healthspan in animal models.
  • Resilience may serve as a key indicator of biological aging and a target for therapeutic interventions.

Purpose of the Study:

  • To explore the potential of resilience testing in animal models as a surrogate for assessing aging.
  • To identify and rank potential stressors for evaluating physiological resilience in aging research.
  • To discuss the development of a standardized battery of tests for resilience in mice.

Main Methods:

  • A meeting of basic researchers and clinicians discussed the merits and drawbacks of using mouse models to study resilience.
Keywords:
AgingHealth SpanResilience

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  • Consideration of various physiological stressors for assessing resilience, including general health relevance, ease of use, cost, reproducibility, clinical relevance, and longitudinal feasibility.
  • Discussion focused on developing a limited, ranked battery of stressors.

    • Main Results:

    • There is a significant need for further research to establish reliable and validated tests for resilience in aging animal models.
    • A preliminary ranking of potential stressors was discussed, acknowledging it as a first attempt.
    • Current knowledge regarding the assessment of resilience in aging is limited.

    Conclusions:

    • Developing accurate and predictable animal models for resilience testing is crucial for aging research.
    • Interventions that enhance resilience could lead to novel treatments for acute illness recovery and prevention of adverse outcomes in older individuals.
    • More research is urgently needed to create appropriate tests for resilience within the aging context.