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MiR-144 suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SMAD4

Min Yu1, Ye Lin1, Yu Zhou1

  • 1Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China.

Oncotargets and Therapy
|August 19, 2016
PubMed
Abstract

Insights

MicroRNA-144 (miR-144) is frequently downregulated in hepatocellular carcinoma (HCC). Restoring miR-144 levels inhibits HCC progression and chemoresistance by targeting SMAD4.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) play a crucial role in the development and progression of hepatocellular carcinoma (HCC).
  • The specific function and regulatory mechanisms of miR-144 in HCC remain largely unexplored.

Purpose of the Study:

  • To investigate the role of miR-144 in hepatocellular carcinoma (HCC).
  • To identify the underlying molecular mechanisms and therapeutic potential of miR-144 in HCC.

Main Methods:

  • Assessed miR-144 expression in HCC cell lines and patient tissues.
  • Examined the functional impact of miR-144 on HCC cell behavior.
  • Identified and experimentally validated the molecular target of miR-144.

Main Results:

  • miR-144 was frequently downregulated in human HCC tissues and cell lines.
  • Overexpression of miR-144 significantly inhibited HCC metastasis, invasion, cell cycle progression, epithelial-mesenchymal transition, and chemoresistance.
  • SMAD4 was identified as a direct and novel target of miR-144 in HCC.

Conclusions:

  • miR-144 plays a tumor-suppressive role in HCC.
  • Overexpression of miR-144 or downregulation of SMAD4 presents potential therapeutic strategies for HCC treatment.
Keywords:
liver cancermicroRNAtherapeautic target

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