Related Experiment Video
Updated: Mar 16, 2026
12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
13.3K
Moderate Aerobic Training Improves Cardiorespiratory Parameters in Elastase-Induced Emphysema
Isabela Henriques1, Miquéias Lopes-Pacheco2, Gisele A Padilha1
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro Rio de Janeiro, Brazil.
Frontiers in Physiology
|August 19, 2016
Summary
Aerobic training improved lung function in an emphysema model by reducing inflammation and remodeling. This exercise intervention also decreased cardiac strain and pulmonary hypertension.
Area of Science:
- Pulmonary Medicine
- Cardiovascular Physiology
- Exercise Science
Background:
- Emphysema is characterized by lung tissue destruction, inflammation, and impaired respiratory mechanics.
- Elastase-induced emphysema in mice serves as a relevant model for studying disease progression and therapeutic interventions.
- Cardiac dysfunction, including right ventricular hypertrophy and pulmonary arterial hypertension, is a common complication of emphysema.
Purpose of the Study:
- To investigate the therapeutic effects of aerobic training on lung mechanics, inflammation, and cardiac function in an elastase-induced emphysema model.
- To assess the impact of exercise on biological markers of inflammation and endothelial cell damage.
- To evaluate changes in lung morphometry and pulmonary arterial pressure following aerobic training.
Main Methods:
- Mice were induced with emphysema using porcine pancreatic elastase or saline control.
- Emphysematous mice were divided into sedentary and aerobic training groups.
- Aerobic training involved treadmill running at moderate intensity for 30 minutes, 3 times per week for 4 weeks.
Main Results:
- Emphysema led to reduced lung elastance, increased collagen and elastic fibers, alveolar hyperinflation, and elevated inflammatory markers (TNF-α, IL-1β).
- Cardiac assessment revealed increased right ventricular diastolic area (RVA) in emphysematous mice, indicating cardiac strain.
- Aerobic training in emphysematous mice reduced hyperinflation, inflammation, collagen deposition, and RVA, while improving lung elastance and VEGF levels.
Conclusions:
- Four weeks of moderate-intensity aerobic training effectively modulated lung inflammation and remodeling in an emphysema model.
- Aerobic exercise improved pulmonary function and reduced markers of cardiac strain and pulmonary arterial hypertension.
- Regular aerobic training demonstrates therapeutic potential for managing emphysema and its associated cardiopulmonary complications.
Related Concept Videos
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.0K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.0K
01:17Exercise and Cardiac Output
2.4K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
2.4K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.0K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
01:20Exercise and Cardiovascular Response
4.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.9K
01:20COPD: Pathogenesis and Clinical Features
2.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K