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Updated: Mar 16, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

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Individualized treatment with infliximab therapy in children with Crohn's disease support shorter time intervals

M Sommar1, S Eksborg2, H Hildebrand3

  • 1Karolinska Pharmacy, Karolinska University Hospital, StockholmSweden.

Journal of Drug Assessment
|August 19, 2016
PubMed

Insights

Individualized infliximab dosing intervals in pediatric Crohn's disease (CD) showed that shorter intervals, less than 8 weeks, maintained remission. Longer intervals were associated with loss of remission in pediatric CD patients.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease affecting children.
  • Infliximab is a biologic therapy used for moderate to severe CD.
  • Optimizing infliximab treatment intervals is crucial for sustained clinical response.

Purpose of the Study:

  • To evaluate the impact of individualized infliximab infusion intervals on clinical outcomes in pediatric Crohn's disease.
  • To determine if physician-guided, flexible dosing strategies improve treatment efficacy.

Main Methods:

  • Retrospective analysis of medical records for pediatric CD patients treated with infliximab.
  • Study included patients from two Swedish counties between 1999 and 2007.
  • Focus on individualized dosage interval adjustments.

Main Results:

  • Twenty-nine pediatric CD patients were analyzed.
  • Most patients lost remission when infliximab dosage intervals exceeded 8 weeks.
  • Individualized treatment often resulted in intervals shorter than 8 weeks.

Conclusions:

  • Individualized treatment approaches for infliximab in pediatric CD frequently led to intervals under 8 weeks.
  • Shorter intervals appear more effective in maintaining remission.
  • Results should be interpreted considering the retrospective study design.
Abstract

Keywords:
ChildrenClinical outcomeCrohn’s diseaseInfliximabMaintenance therapy

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