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A Complication Analysis of 2 Acellular Dermal Matrices in Prosthetic-based Breast Reconstruction
Orion P Keifer1, Eugenia K Page1, Alexandra Hart1
1Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga.
Plastic and Reconstructive Surgery. Global Open
|August 19, 2016
Summary
Acellular dermal matrices (ADM) like AlloDerm and Cortiva show similar complication rates in breast reconstruction. Current tobacco use, not ADM type, predicts complications.
Area of Science:
- Plastic Surgery
- Reconstructive Surgery
- Biomaterials Science
Background:
- Acellular dermal matrices (ADM) are standard in prosthetic-based breast reconstruction.
- This study compares complication rates between two common ADM products: AlloDerm and Cortiva.
Purpose of the Study:
- To evaluate and compare the early complication frequencies of AlloDerm and Cortiva in prosthetic-based breast reconstruction.
- To identify predictors of complications in this patient population.
Main Methods:
- Retrospective analysis of 298 prosthetic-based breast reconstructions over 5 years.
- Inclusion criteria: use of AlloDerm or Cortiva ADM with tissue expander or implant.
- Statistical comparison of demographics, risk factors, and early complications between ADM groups.
Main Results:
- No significant difference in overall complication frequency between AlloDerm (16/174) and Cortiva (18/124) (P=0.195).
- Mastectomy skin flap necrosis was linked to body mass index (P=0.036), not ADM type.
- Current tobacco use (P=0.033) was the only significant predictor of complications; BMI and age were trending predictors (P<0.1).
Conclusions:
- Cortiva demonstrates equivalent complication frequency to the established AlloDerm in breast reconstruction.
- ADM type was not a significant predictor of complications.
- Future research should explore long-term outcomes and histological integration.
