Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Stem Cell Culture01:17

Stem Cell Culture

6.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.5K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.9K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of the ratio of non-HDL-cholesterol to HDL-cholesterol with clinical and pathological characteristics in diabetic kidney disease.

BMC nephrology·2026
Same author

The versatile roles of long non-coding RNAs in kidney disease.

Nature reviews. Nephrology·2026
Same author

A Target Trial Emulation to Investigate Kidney Protection from Statin Initiation in Adults with Normal Kidney Function.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Finerenone in Patients With Chronic Kidney Disease Due to Glomerular Diseases: A Randomized Clinical Trial.

JAMA·2026
Same author

Global Treatment Patterns for Immunoglobulin A Nephropathy in Adults: Results from a Real-World Survey.

Glomerular diseases·2026
Same author

Current understanding of sodium-glucose transporter 2 inhibitors in cardiovascular-kidney-metabolic syndrome.

Frontiers in pharmacology·2026

Related Experiment Video

Updated: Mar 16, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.9K

Recent Progress in Stem Cell Therapy for Diabetic Nephropathy.

Yang Liu1, Sydney C W Tang1

  • 1Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, China.

Kidney Diseases (Basel, Switzerland)
|August 19, 2016
PubMed
Summary
This summary is machine-generated.

Diabetic nephropathy (DN) treatment is limited, but stem cell therapy shows promise for kidney regeneration. Advances in differentiating stem cells offer new avenues for investigating DN mechanisms and potential therapies.

Keywords:
Diabetic nephropathyInduced pluripotent stem cellsMesenchymal stem cellsStem cell therapy

More Related Videos

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
11:13

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

9.6K
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

6.1K

Related Experiment Videos

Last Updated: Mar 16, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.9K
Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
11:13

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

9.6K
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

6.1K

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Diabetic nephropathy (DN) is a leading cause of end-stage renal disease with limited treatment options.
  • Current therapies cannot halt the progression of DN towards end-stage renal disease.
  • Stem cell-based therapy has demonstrated potential in preclinical models of kidney disease, including DN.

Purpose of the Study:

  • To review recent advancements in stem cell-based therapies for diabetic nephropathy.
  • To highlight the progress and limitations of using stem cells for DN treatment.
  • To discuss the potential of stem cells in regenerating injured kidney tissues.

Main Methods:

  • Review of current literature on stem cell therapy for DN.
  • Analysis of different stem cell types (ESCs, MSCs, iPSCs) and their mechanisms of action.
  • Evaluation of challenges and recent breakthroughs in stem cell differentiation and application for DN.

Main Results:

  • Stem cells can regenerate injured kidneys through homing, differentiation, paracrine effects, and immunoregulation.
  • Podocytes and proximal tubular epithelial cells are key targets in DN pathogenesis.
  • Progress in differentiating human ESCs and iPSCs into renal cells offers new research tools.

Conclusions:

  • Stem cell therapy holds significant promise for treating diabetic nephropathy.
  • Overcoming challenges like poor cell survival and inadequate animal models is crucial for clinical success.
  • Patient-specific iPSCs and direct differentiation methods are advancing DN research and therapeutic development.