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Completed suicide, depression, and RELN polymorphisms.

Marina Bučić1, Peter Pregelj, Tomaž Zupanc

  • 1aInstitute of Biochemistry bDepartment of Psychiatry cInstitute of Forensic Medicine, Faculty of Medicine, University of Ljubljana dUniversity Psychiatric Hospital Ljubljana, Ljubljana, Slovenia.

Psychiatric Genetics
|August 19, 2016
PubMed
Summary
This summary is machine-generated.

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This study explored the genetic link between the reelin gene and suicidal behavior. A specific reelin gene polymorphism (rs2965087) was associated with suicide threats and family history of suicide, but not general depression symptoms.

Area of Science:

  • Genetics
  • Psychiatry
  • Behavioral Science

Background:

  • Suicidal behavior is a complex trait influenced by genetic and environmental factors.
  • The reelin gene has been previously linked to psychiatric disorders like depression.

Purpose of the Study:

  • To investigate the association between specific single nucleotide polymorphisms (SNPs) in the reelin gene and suicidal behavior.
  • To explore potential correlations with suicide threats, family history of suicide, and depression symptoms.

Main Methods:

  • Analysis of three reelin gene SNPs (rs2965087, rs7341475, rs362691) in 483 Caucasian suicide victims and 332 controls.
  • Psychological autopsy data from 77 suicide victims were used to assess suicide threats, family history, and depression symptoms.

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Main Results:

  • No general association found between the studied reelin gene SNPs and suicide.
  • A significant association was observed between the rs2965087 TT genotype and prior suicide announcements and family history of suicide.
  • Individuals with the rs2965087 TT genotype exhibited fewer depressive symptoms, excluding suicidal threats.

Conclusions:

  • The reelin gene polymorphism rs2965087 may be associated with specific aspects of suicidal behavior, particularly suicidal threats.
  • Limitations include potential recall bias and a small sample size, necessitating further research.