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Non-invasive Respiratory Support and Severe Retinopathy of Prematurity

Rahul Raghu, Marilyn Fisher, Jennifer Cerone

    Journal of Pediatric Ophthalmology and Strabismus
    |August 19, 2016
    PubMed

    Insights

    Two premature infants developed severe retinopathy of prematurity (ROP) despite minimal oxygen exposure. Noninvasive respiratory support may be linked to aggressive ROP, warranting further investigation.

    Area of Science:

    • Ophthalmology
    • Neonatology
    • Perinatal Medicine

    Background:

    • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
    • Oxygen exposure is a known risk factor for ROP development.
    • Noninvasive respiratory support is commonly used in premature infants.

    Observation:

    • Two cases of premature infants with stage 3, zone I ROP and plus disease are presented.
    • Both infants had limited exposure to supra-ambient oxygen.
    • Both infants received noninvasive respiratory support for several weeks.

    Findings:

    • The ROP observed was unusually posterior and aggressive for the infants' gestational ages and birth weights.
    • These findings suggest a potential association between noninvasive respiratory support and severe ROP.
    • The limited oxygen exposure in these cases challenges conventional understanding of ROP etiology.

    Implications:

    • Further research is needed to confirm the link between noninvasive respiratory support and severe ROP.
    • This study highlights the need to re-evaluate risk factors for ROP, especially in infants receiving respiratory support.
    • Understanding these associations can lead to improved preventative strategies and clinical management for ROP.

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