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Related Experiment Video

Updated: Mar 16, 2026

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

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Optical Defocus Rapidly Changes Choroidal Thickness in Schoolchildren.

Danyang Wang1,2,3, Rachel Ka Man Chun2, Manli Liu1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China.

Plos One
|August 19, 2016
PubMed
Summary

Short-term optical defocus rapidly altered choroidal thickness in myopic children. Hyperopic defocus thinned the choroid, while myopic defocus thickened it, showing a reversible response to visual stimuli.

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Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
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Area of Science:

  • Ophthalmology
  • Vision Science
  • Pediatric Optometry

Background:

  • Myopia progression is a significant concern in children.
  • Optical defocus is implicated in myopia development and progression.
  • Understanding the eye's response to defocus is crucial for myopia management.

Purpose of the Study:

  • To investigate the short-term effects of myopic and hyperopic defocus on choroidal thickness in myopic children.
  • To assess the reversibility of these choroidal changes after defocus removal.

Main Methods:

  • A randomized controlled trial involving 51 myopic schoolchildren aged 8-16.
  • Groups received either myopic defocus (+3D), hyperopic defocus (-3D), or full correction (control) for 2 hours.
  • Axial length and subfoveal choroidal thickness were measured hourly for 4 hours using spectral domain optical coherence tomography.

Main Results:

  • Hyperopic defocus led to significant choroidal thinning.
  • Myopic defocus resulted in less thinning compared to the control group.
  • Choroidal thickness changes were rapid and reversible upon removal of optical defocus.

Conclusions:

  • Short-term myopic defocus induces relative choroidal thickening, while hyperopic defocus causes thinning in children.
  • The rapid and reversible choroidal response to optical defocus may serve as a clinical indicator in myopia research.