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Effects of Deep Brain Stimulation on Autonomic Function.

Adam Basiago1, Devin K Binder2

  • 1School of Medicine, University of California, Riverside, CA 92521, USA. adam.basiago@email.ucr.edu.

Brain Sciences
|August 19, 2016
PubMed
Summary

Deep brain stimulation (DBS) shows promise for treating autonomic dysfunction in neurological diseases. Studies reveal DBS can modulate blood pressure, breathing, and bladder control by targeting specific brain areas.

Keywords:
autonomic dysfunctionblood pressuredeep brain stimulationgastrointestinal motilityglobus pallidus internamicturitionperiaqueductal or periventricular graysubthalamic nucleussweatingthalamus

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Area of Science:

  • Neurology
  • Neurosurgery
  • Autonomic Neuroscience

Background:

  • Autonomic dysfunction is prevalent in neurological disorders like Parkinson's disease, essential tremor, and dystonia.
  • Deep brain stimulation (DBS) is an established therapy for movement disorders.
  • Emerging evidence suggests DBS may treat autonomic dysfunction.

Purpose of the Study:

  • To review the effects of DBS on autonomic functions.
  • To summarize studies investigating DBS for autonomic dysfunction.
  • To highlight the impact of stimulation targets on autonomic responses.

Main Methods:

  • Literature review of studies on DBS and autonomic function.
  • Analysis of reported effects on cardiovascular, respiratory, and genitourinary systems.
  • Examination of studies modulating the sympathetic nervous system.

Main Results:

  • DBS can alter blood pressure and normalize baroreflex.
  • Modulation of sympathetic nervous system by DBS impacts bronchiole caliber and sweating.
  • DBS influences bladder control, micturition reflexes, swallowing, and gastric emptying.

Conclusions:

  • DBS demonstrates potential for treating various autonomic dysfunctions.
  • The effects of DBS on autonomic function are target-dependent.
  • Further research is warranted to optimize DBS for autonomic disorders.