Related Experiment Video
Updated: Mar 16, 2026

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
2.6K
Painful thyroid nodule, a misleading presentation of subacute thyroiditis
Corinne Jonas1, Claude Bertrand2, Luc Michel2
1a Department of Endocrinology , CHU Dinant-Godinne , Yvoir , Belgium.
Acta Chirurgica Belgica
|August 19, 2016
Summary
Subacute thyroiditis (SAT) can present as a painful thyroid nodule, mimicking cancer. Awareness of this atypical presentation prevents unnecessary thyroid surgery.
Area of Science:
- Endocrinology
- Thyroidology
- Diagnostic Imaging
Background:
- Subacute thyroiditis (SAT) typically presents with neck pain, fever, and hyperthyroidism, characterized by low radioactive iodine uptake.
- Classical diagnostic features include anterior neck pain radiating to the jaw/ear, asthenia, and inflammatory markers.
Observation:
- This report details two cases where subacute thyroiditis manifested initially as a painful thyroid nodule.
- Ultrasound revealed heterogeneous, hypoechoic, ill-defined areas with low vascularity, leading to suspicion of malignancy.
Findings:
- The clinical and imaging findings in these cases mimicked thyroid cancer, prompting consideration of surgical intervention.
- Histopathological examination post-surgery would be required to confirm the diagnosis if surgery were performed.
Implications:
- Clinicians must recognize that subacute thyroiditis can present atypically as a painful thyroid nodule.
- Increased awareness can prevent misdiagnosis and avoid unnecessary surgical procedures for subacute thyroiditis.
Related Concept Videos
Acute Pharyngitis
5.3K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
5.3K
Tonsillitis I: Introduction
2.9K
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
2.9K
Synthesis and Regulation of Thyroid Hormones
8.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.7K
Myocarditis II: Clinical Features and Diagnostic Tests
402
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
402
Chronic Pharyngitis
14.1K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
14.1K
Myasthenia Gravis: Overview and Treatment
3.3K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.3K

