Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

2.3K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.3K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.5K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.5K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

26.8K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.8K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

3.4K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
3.4K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.8K
Regulated mRNA Transport02:22

Regulated mRNA Transport

7.1K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The concept of the Model Law "On social advertisement in the field of healthy life-style"].

Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny·2021
Same author

[Expanding the Genetic Code: Unnatural Base Pairs in Biological Systems].

Molekuliarnaia biologiia·2020
Same author

[Food-derived opioid peptides and their neurological impact].

Uspekhi fiziologicheskikh nauk·2015
Same author

The effects of new nociceptin analogs on the behavior of white rats.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2013
Same author

Receptor-binding domain of ephrin-A1: production in bacterial expression system and activity.

Biochemistry. Biokhimiia·2012
Same author

[Isolation and functional characterization of lipase from the thermophilic alkali-tolerant bacterium Thermosyntropha lipolytica].

Prikladnaia biokhimiia i mikrobiologiia·2012

Related Experiment Video

Updated: Mar 16, 2026

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
11:48

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

Published on: July 13, 2011

36.0K

[Local Protein Synthesis in Dendrites and its Regulation Normally and During Plastic Changes].

E A Chesnokova, P M Kolosov

    Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova
    |August 20, 2016
    PubMed
    Summary

    This review covers how proteins are synthesized within dendrites and the mechanisms that control this process. Malfunctions in dendritic protein synthesis are linked to neurological diseases.

    More Related Videos

    3D Modeling of Dendritic Spines with Synaptic Plasticity
    07:13

    3D Modeling of Dendritic Spines with Synaptic Plasticity

    Published on: May 18, 2020

    7.5K
    Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
    08:30

    Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient

    Published on: September 17, 2011

    33.1K

    Related Experiment Videos

    Last Updated: Mar 16, 2026

    Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
    11:48

    Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

    Published on: July 13, 2011

    36.0K
    3D Modeling of Dendritic Spines with Synaptic Plasticity
    07:13

    3D Modeling of Dendritic Spines with Synaptic Plasticity

    Published on: May 18, 2020

    7.5K
    Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
    08:30

    Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient

    Published on: September 17, 2011

    33.1K

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Cell Biology

    Background:

    • Dendrites are crucial neuronal structures involved in receiving and processing signals.
    • Protein synthesis within dendrites (dendritic translation) is essential for synaptic plasticity and neuronal function.
    • Dysregulation of dendritic translation is implicated in various neurological disorders.

    Purpose of the Study:

    • To review the specifics and key regulatory mechanisms of compartmentalized protein synthesis in dendrites.
    • To analyze up-to-date literature data on dendritic translation.
    • To present findings from molecular, cytological, and physiological experiments.

    Main Methods:

    • Literature review and analysis of existing experimental data.
    • Synthesis of findings from molecular experiments.
    • Integration of cytological and physiological evidence.

    Main Results:

    • Detailed overview of the regulation mechanisms governing localized protein synthesis in dendrites.
    • Presentation of experimental results highlighting the importance of dendritic translation.
    • Identification of links between impaired dendritic translation and neurological diseases.

    Conclusions:

    • Compartmentalized protein synthesis in dendrites is a tightly regulated process.
    • Aberrant dendritic translation contributes to the pathophysiology of neurological diseases.
    • Further research into these mechanisms could reveal therapeutic targets.