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Published on: April 11, 2016
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Precision medicine, genomics and drug discovery
1Target Sciences, GlaxoSmithKline, King of Prussia, PA, USA lon.r.cardon@gsk.com.
Human Molecular Genetics
|August 20, 2016
Summary
Precision medicine advances oncology and rare diseases, but complex common diseases lag. Future efforts may leverage electronic health records and digital health for better treatment refinement.
Area of Science:
- Biomedical Sciences
- Genomics
- Pharmacology
Background:
- Precision medicine, long envisioned, is now a reality in oncology and rare disease drug discovery.
- While significant progress has been made in personalized treatments and therapies for rare diseases, common complex diseases remain a challenge.
Approach:
- Leveraging advances in genomics, including Genome-Wide Association Studies (GWAS), to understand genetic architecture.
- Exploring novel drug delivery modalities such as cell and gene therapy and oligonucleotide approaches.
- Utilizing population-based resources like electronic health records (EHRs) and digital health tools.
Key Points:
- Oncology and rare diseases have seen successful implementation of precision medicine, with personalized treatments and new drug approvals.
- Genome-Wide Association Studies (GWAS) have improved understanding of genetic architecture but haven't translated to refined treatments for common complex diseases.
- Pharmacogenetic studies have faced challenges in predicting treatment response, possibly due to the multifactorial nature and heterogeneity of common diseases.
Conclusions:
- Precision medicine has yielded significant successes in oncology and rare diseases, demonstrating the potential of targeted therapies.
- Common complex diseases present unique challenges due to their multifactorial nature and heterogeneity, requiring novel approaches.
- Integrating electronic health records and digital health technologies may enhance phenotypic outcome measurement, facilitating progress in treating common diseases.
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