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Inflammasome Activation in Chronic Glomerular Diseases

Sabena M Conley1, Justine M Abais1, Krishna M Boini2

  • 1Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, Richmond, VA, 23298. United States.

Current Drug Targets
|August 20, 2016
PubMed
Summary

The NLRP3 inflammasome, a key player in inflammation, is implicated in kidney diseases like end-stage renal disease (ESRD). Its activation in glomerular cells contributes to kidney injury and disease progression.

Keywords:
Inflammationdiabetes mellitusglomerulosclerosishomocysteineinflammasome

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