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Mannose Binding Lectin: A Potential Biomarker for Many Human Diseases
Senjam Sunil Singh1, Randy Chi Fai Cheung2, Jack Ho Wong
1Laboratory of Protein Biochemistry, Biochemistry Department, Manipur University, Canchipur, Imphal-795003, India. sunil_senjam@rediffmail.com.
Current Medicinal Chemistry
|August 20, 2016
Summary
Mannose-binding lectin (MBL) is crucial in innate immunity and complement activation. Measuring MBL levels offers prognostic value for diseases and highlights MBL as a potential therapeutic target.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- The innate immune system modulates inflammation during infection and tissue repair.
- Mannose-binding lectin (MBL) is a key component of innate immunity, initiating the lectin complement pathway.
- Complement system activation is implicated in various human diseases.
Purpose of the Study:
- To summarize the prognostic value of early serum Mannose-binding lectin (MBL) detection and level measurement.
- To discuss the dual role of MBL in human diseases, acting as both a contributor to pathology and a defense mechanism.
- To highlight MBL as a diagnostic biomarker and potential therapeutic target.
Main Methods:
- Review of current evidence on MBL's role in disease pathophysiology.
- Analysis of MBL2 gene variants and their association with infection risk.
- Evaluation of MBL measurement as a diagnostic tool.
Main Results:
- MBL plays a complex, dual role in human diseases.
- MBL2 gene polymorphisms are linked to increased infection susceptibility.
- Early MBL detection shows prognostic significance.
Conclusions:
- Serum MBL determination is important for disease diagnosis.
- MBL represents a novel therapeutic target for various human diseases.
- Recombinant or plasma-purified MBL may offer therapeutic potential.
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