Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proximity of the Histone-Acetylation Site to the Termini Shapes Phase Behavior with DNA.

Journal of the American Chemical Society·2026
Same author

Rapid detection and strain-level identification of milk-borne bacteria using a polymer-based chemical tongue.

Journal of materials chemistry. B·2026
Same author

A fingerprint-based polymeric sensing platform for comprehensive quality assessment of complex culture media in cell manufacturing.

Chemical science·2026
Same author

Mesopore-Depth Optimization in Mesoporous Gold Films for SF<sub>6</sub> Electroreduction.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Alteration in the Sensitivity of Firefly Bioluminescence to pH Driven by Molecular Recruitment to Coacervate Droplets.

ACS omega·2025
Same author

Discovery of Pseudo-Luciferase Activity in Immunoglobulin G (IgG) and Its Application to the Detection of IgG Denaturation.

Analytical chemistry·2025

Related Experiment Video

Updated: Mar 16, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K

Microfluidic platforms for DNA methylation analysis.

Ryoji Kurita1, Osamu Niwa

  • 1Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) and DAILAB, Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566 Japan. r.kurita@aist.go.jp.

Lab on a Chip
|August 20, 2016
PubMed
Summary

Epigenetics studies gene expression changes without altering DNA sequences. Microfluidic platforms offer a high-throughput, sensitive method for analyzing DNA methylation, a key epigenetic mechanism.

More Related Videos

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.3K
Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

19.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.3K
Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

19.4K

Area of Science:

  • Genetics
  • Molecular Biology
  • Biotechnology

Background:

  • Epigenetics involves changes in gene expression without altering DNA sequences.
  • DNA methylation, particularly 5'-methylcytosine in CpG sites, is a primary epigenetic mechanism.
  • Accurate DNA methylation analysis is crucial for diagnosis, drug discovery, and therapy.

Purpose of the Study:

  • To review the field of epigenetics.
  • To discuss advancements in DNA methylation analysis methods.
  • To highlight the application of microfluidic platforms in DNA methylation analysis.

Main Methods:

  • Review of existing literature on epigenetics and DNA methylation analysis.
  • Discussion of conventional methods for analyzing DNA methylation and DNA methyltransferase activity.
  • Exploration of microfluidic technologies for high-throughput DNA methylation analysis.

Main Results:

  • Conventional methods for DNA methylation analysis are often time-consuming and complex.
  • Microfluidic platforms enable thousands of DNA methylation reactions in small volumes.
  • Microfluidics offers high-throughput and high-sensitivity analysis for DNA methylation.

Conclusions:

  • Microfluidic technology presents a promising advancement for DNA methylation analysis.
  • This technology can accelerate research in epigenetics and its applications.
  • Further development of microfluidic platforms is essential for the field.