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Effect of hydergine in hyperprolactinemia
T Tamura1, T Satoh, H Minakami
1Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi Prefecture, Japan.
The Journal of Clinical Endocrinology and Metabolism
|August 1, 1989
Summary
Hydergine effectively lowers prolactin (PRL) levels, inducing ovulation in women with hyperprolactinemic anovulatory disturbances and serum PRL below 100 micrograms/L. It showed limited success in normalizing PRL or inducing ovulation in patients with higher PRL levels.
Area of Science:
- Endocrinology
- Reproductive Medicine
Background:
- Hyperprolactinemia is associated with ovulatory disturbances.
- Effective treatments for hyperprolactinemic anovulatory disorders are crucial for fertility.
Purpose of the Study:
- To investigate the prolactin (PRL)-inhibiting and ovulation-inducing effects of hydergine.
- To assess hydergine's efficacy in patients with varying basal serum PRL levels.
Main Methods:
- 18 patients with hyperprolactinemic ovulatory disturbances were divided into two groups based on basal serum PRL levels (<100 and >100 micrograms/L).
- Patients received either hydergine or placebo orally, with serum PRL levels monitored over 8 hours.
- Chronic treatment was administered to assess long-term effects on PRL normalization and ovulation.
Main Results:
- Hydergine significantly reduced serum PRL levels in both groups compared to placebo.
- In patients with basal PRL <100 micrograms/L, hydergine normalized PRL levels and induced ovulation in 78%, leading to pregnancies and live births.
- In patients with basal PRL >100 micrograms/L, hydergine showed limited success in normalizing PRL or inducing ovulation.
Conclusions:
- Hydergine possesses significant PRL inhibitory activity.
- Hydergine is a potentially useful treatment for hyperprolactinemic anovulatory patients with basal serum PRL concentrations below 100 micrograms/L.
- No significant side-effects were reported during the trials.