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Relation of serum irisin level with metabolic and antropometric parameters in obese children

Gönül Çatlı1, Tuncay Küme2, Hale Ünver Tuhan3

  • 1Department of Pediatric Endocrinology, Katip Celebi University, Faculty of Medicine, Izmir.

Journal of Diabetes and Its Complications
|August 20, 2016
PubMed

Insights

Obese children show higher serum irisin levels compared to healthy children. Irisin is linked to insulin sensitivity and lipid metabolism in childhood obesity.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Health

Background:

  • Childhood obesity is a growing global health concern.
  • Irisin, a myokine, plays a role in energy metabolism.
  • Understanding irisin's role in pediatric obesity is crucial for metabolic health.

Purpose of the Study:

  • To investigate the association between serum irisin levels and metabolic/anthropometric parameters in obese children.
  • To compare irisin levels between obese and healthy children.
  • To explore irisin's relationship with insulin resistance and lipid profiles.

Main Methods:

  • Study included 36 obese children (BMI ≥95th percentile) and 30 healthy controls.
  • Measured anthropometric, biochemical (glucose, insulin, lipids, leptin, irisin), and body composition parameters.
  • Utilized bioelectric impedance analysis for body fat percentage and fat mass determination.

Main Results:

  • Obese children exhibited significantly higher serum irisin and leptin levels than healthy controls.
  • Irisin levels correlated with high-density lipoprotein cholesterol (HDL-C), fasting insulin, and HOMA-IR.
  • Multivariate analysis indicated age, HOMA-IR, and HDL-C significantly associated with serum irisin.

Conclusions:

  • Obese children have elevated serum irisin levels compared to their healthy peers.
  • Evidence suggests irisin influences insulin sensitivity and lipid metabolism in pediatric obesity.
  • Further research into irisin's therapeutic potential for childhood obesity is warranted.
Abstract

Keywords:
ChildrenFat massInsulin resistanceIrisinLeptinObesity

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