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A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

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A REALLY WHEEZY WAY TO SAVE MONEY.

Grace Li¹, Ofran Almossawi¹, Hasna Dulfeker¹

¹North Middlesex University Hospital.

Archives of Disease in Childhood

|August 20, 2016

Summary

Switching to non-soluble prednisolone in children showed similar acceptance rates to soluble forms. Masking the taste improved palatability, offering significant cost savings for the NHS without impacting patient care.

Area of Science:

Paediatric pharmacology
Clinical pharmacy
Quality improvement initiatives

Background:

Oral prednisolone is a common treatment for paediatric conditions like asthma.
Soluble formulations are often preferred for palatability but are more expensive.
Non-soluble formulations offer significant cost savings but raise concerns about taste and compliance.

Purpose of the Study:

To compare the palatability and tolerability of oral non-soluble versus oral soluble prednisolone in paediatric patients.
To assess the impact of formulation changes on medication acceptance and potential cost savings.

Main Methods:

A comparative study involving 27 paediatric patients over two three-week periods.
Palatability and tolerance (swallowing, refusal, vomiting) were measured using a modified 5-point hedonic scale.

Keywords:

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Data were collected by ward doctors and nurses.

Main Results:

Similar acceptance rates were observed for both soluble and non-soluble prednisolone formulations.
Two non-tolerated doses occurred with the soluble form (n=17) versus three with the non-soluble form (n=10).
Masking the taste of non-soluble prednisolone with sugar-free jam or cordial improved acceptance, though both formulations were sometimes disliked.

Conclusions:

The switch to non-soluble prednisolone is feasible for paediatric inpatients and take-home medications.
Significant annual cost savings of over £44,000 were achieved for the Trust alone.
The switch to non-soluble prednisolone can lead to substantial NHS savings without compromising clinical care, supported by parent information leaflets.