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Disseminated intravascular coagulation in paediatrics
Revathi Rajagopal1, Jecko Thachil2, Paul Monagle3,4,5
1Paediatric Haemato-Oncology, Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.
Archives of Disease in Childhood
|August 20, 2016
Summary
Pediatric disseminated intravascular coagulation (DIC) presents unique challenges due to age-related differences in hemostasis. This review clarifies DIC
Area of Science:
- Pediatric Hematology
- Hemostasis and Thrombosis
Background:
- Disseminated intravascular coagulation (DIC) in children leads to severe illness and death.
- Adult DIC research is more advanced than pediatric studies, despite crucial differences in early-life hemostasis.
- Delayed diagnosis of pediatric DIC is common due to the evolving nature of the hemostatic system in children.
Purpose of the Study:
- To review the causes, mechanisms, and symptoms of pediatric DIC.
- To outline diagnostic methods for DIC in children.
- To provide a management algorithm for pediatricians treating DIC.
Main Methods:
- Literature review focusing on pediatric DIC.
- Synthesis of current knowledge on DIC pathophysiology and clinical presentation.
- Development of a practical management guideline.
Main Results:
- DIC in children has distinct etiologies and pathophysiology compared to adults.
- Early recognition and diagnosis are critical but challenging.
- A structured approach to diagnosis and management is essential.
Conclusions:
- Understanding the unique aspects of pediatric hemostasis is key to managing DIC.
- Prompt diagnosis and appropriate management algorithms can improve outcomes.
- This review offers guidance for clinicians facing pediatric DIC.
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