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Hepatitis D Virus: A Call to Screening.

Joseph Ahn1, Robert G Gish1

  • 1Dr Ahn is an associate professor of medicine at Oregon Health & Science University in Portland, Oregon. Dr Gish is a clinical professor of medicine (consultant) at Stanford Hospital and Medical Center in Stanford, California; clinical professor of medicine (adjunct) at the University of Nevada in Las Vegas, Nevada; senior medical director at St Joseph's Hospital and Medical Center in Phoenix, Arizona; vice chair of the National Viral Hepatitis Roundtable in San Francisco, California; medical director of the Hepatitis B Foundation in Doylestown, Pennsylvania; and principal of Robert G. Gish Consultants, LLC, in San Diego, California.

Gastroenterology & Hepatology
|August 20, 2016
PubMed
Summary
This summary is machine-generated.

Hepatitis D virus (HDV) causes severe liver disease, requiring hepatitis B coinfection. Increased awareness and improved diagnostics are driving new screening and therapy efforts for this "forgotten virus".

Keywords:
Hepatitis deltacirrhosisinterferonpegylated interferonprenylation inhibitors

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Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis D virus (HDV) infection leads to aggressive viral hepatitis, characterized by rapid progression to cirrhosis and hepatic decompensation.
  • HDV pathogenesis and propagation are dependent on coinfection with the hepatitis B virus (HBV).
  • HDV has historically been overlooked, suffering from reduced public awareness, medical interest, and research funding.

Purpose of the Study:

  • To provide a framework for understanding the reasons behind the renewed impetus for increased Hepatitis D virus screening.
  • To identify critical issues for directing collaborative efforts in Hepatitis D virus research and therapy.

Main Methods:

  • Review of recent advancements in diagnostic testing for HDV.
  • Analysis of international collaborative initiatives focused on improving HDV therapy.
  • Framework development for understanding screening drivers and collaborative targets.

Main Results:

  • There is a resurgence in awareness and interest surrounding HDV.
  • Improvements in diagnostic capabilities are facilitating better detection of HDV.
  • International collaborations are being established to enhance therapeutic strategies for HDV.

Conclusions:

  • The aggressive nature of HDV necessitates increased attention and improved management strategies.
  • Enhanced screening protocols are crucial for early detection and intervention.
  • Collaborative international efforts are vital for advancing research and developing effective therapies for HDV.