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Updated: Mar 16, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Adjunctive intra-coronary imaging for the assessment of coronary artery disease
Nikunj Shah1, Bassey Ussen2, Michael Mahmoudi3
1Department of Cardiology, Ashford & St Peter's Hospitals NHS Foundation Trust, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Insights
Intracoronary imaging, including intravascular ultrasound and optical coherence tomography, improves the diagnosis and treatment of coronary artery disease by reducing variability compared to traditional angiography. These advanced techniques offer superior insights for managing acute coronary syndromes.
Area of Science:
- Cardiology
- Medical Imaging
- Interventional Cardiology
Background:
- Atherosclerotic coronary artery disease is a major global health concern.
- Invasive angiography is the standard for diagnosing and treating coronary disease, but suffers from observer variability in assessing lesion severity.
- Advanced intravascular imaging technologies have been developed to enhance diagnostic accuracy.
Purpose of the Study:
- To discuss the principles, technical aspects, and applications of intravascular ultrasound (IVUS) and optical coherence tomography (OCT).
- To highlight the role of intracoronary imaging in optimizing percutaneous coronary interventions.
- To demonstrate the superiority of adjunctive intracoronary imaging over angiography alone in specific clinical scenarios.
Main Methods:
- Review of the principles and technical considerations of IVUS and OCT.
- Discussion of clinical applications in interventional cardiology.
- Case examples illustrating the benefits of IVUS and OCT in acute coronary syndromes.
Main Results:
- Intracoronary imaging provides crucial information for interventional cardiologists.
- IVUS and OCT help overcome limitations of traditional angiography in lesion assessment.
- Case studies show improved identification and treatment of acute coronary syndromes with adjunctive imaging.
Conclusions:
- Intravascular imaging modalities like IVUS and OCT are essential tools in modern interventional cardiology.
- These techniques enhance the accuracy of diagnosis and treatment planning for coronary artery disease.
- Adjunctive intracoronary imaging leads to better outcomes in managing complex coronary lesions and acute coronary syndromes.
Abstract:
Atherosclerotic coronary artery disease remains a leading cause of worldwide morbidity and mortality. Invasive angiography currently remains the gold standard method of diagnosing and treating coronary disease; however, more sophisticated adjunctive interventional technologies have been developed to combat the inter and intra-observer variability frequently encountered in the assessment of lesion severity. Intravascular imaging now plays a key role in optimising percutaneous coronary interventions and provides invaluable information as part of the interventional cardiologist's diagnostic arsenal. The principles, technical aspects and uses of two modalities of intracoronary imaging, intravascular ultrasound and optical coherence tomography, are discussed. We additionally provide examples of cases where the adjunctive intracoronary imaging was superior to angiography alone in successfully identifying and treating acute coronary syndromes.
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Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

