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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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MicroRNA-Based Linkage between Aging and Cancer: from Epigenetics View Point

Saeid Saeidimehr1, Ammar Ebrahimi2, Najmaldin Saki3

  • 1Naft Grand Hospital, Ahvaz, Iran.

Cell Journal
|August 20, 2016
PubMed

Insights

MicroRNAs (miRNAs) link aging and cancer through genetic and epigenetic mechanisms. Inhibiting antioxidant pathways with miRNAs offers a novel strategy for age-related cancer prevention and treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Gerontology

Background:

  • Aging involves complex physical, psychological, and social changes.
  • Age-related diseases can complicate cancer treatment and recovery.
  • MicroRNAs (miRNAs) are key regulators of gene expression.

Purpose of the Study:

  • To review miRNA functions in aging, focusing on malignancies.
  • To explore genetic, molecular, and epigenetic mechanisms linking aging and cancer.
  • To discuss novel therapeutic strategies involving miRNAs.

Main Methods:

  • Literature review of current research on miRNAs, aging, and cancer.
  • Analysis of genomic and epigenomic data related to miRNA expression.
  • Synthesis of findings on uric acid's role in oxidative stress and cancer.

Main Results:

  • Evidence shows a dynamic, complex link between miRNAs, aging, and cancer at genomic and epigenomic levels.
  • miRNA dysregulation is implicated in age-related malignancies.
  • Uric acid's role in regulating reactive oxygen species (ROS) suggests new therapeutic avenues.

Conclusions:

  • Understanding miRNA-based mechanisms is crucial for age-related cancer and aging.
  • Targeting miRNA inhibition of the SLC2A9 antioxidant pathway presents a novel approach for cancer therapy.
  • miRNAs offer potential for both cancer prevention and treatment in aging populations.
Keywords:
AgeingDisabilityGenomicsLongevityMicroRNAs

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