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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

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Current Biosafety Considerations in Stem Cell Therapy.

Masoumeh Mousavinejad1, Peter W Andrews1, Elham Kargar Shoraki2

  • 1Centre for Stem Cell Biology (CSCB), Department of Biomedical Science, The University of Sheffield, Sheffield, UK.

Cell Journal
|August 20, 2016
PubMed
Summary
This summary is machine-generated.

Stem cell therapies offer great promise for treating diseases, but safety concerns like tumor formation and immune rejection must be addressed. Further research is crucial to ensure the biosafety of these powerful regenerative medicine tools.

Keywords:
ImmunogenicitySafetyTumorigenicity

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Area of Science:

  • * Regenerative Medicine
  • * Developmental Biology
  • * Translational Science

Background:

  • * Stem cells are valuable for disease modeling, drug discovery, and understanding early development.
  • * Controlling stem cell differentiation is key for generating specialized cells for therapeutic use.
  • * Stem cell therapies hold significant potential for treating various diseases.

Purpose of the Study:

  • * To highlight the critical importance of biosafety in stem cell-based therapies.
  • * To identify key risks associated with stem cell clinical applications.
  • * To emphasize the need for comprehensive risk assessment technologies.

Main Methods:

  • * Review of current scientific literature on stem cell applications and safety.
  • * Analysis of intrinsic and extrinsic factors contributing to stem cell therapy risks.
  • * Identification of knowledge gaps in therapeutic applications and biosafety.

Main Results:

  • * Tumorigenicity and immunogenicity are primary risks in cell-based therapies.
  • * Both intrinsic cell properties and extrinsic manufacturing factors can lead to adverse events.
  • * Significant knowledge gaps exist regarding the long-term safety and efficacy of stem cell therapies.

Conclusions:

  • * Biosafety concerns are paramount and potentially outweigh therapeutic efficacy in current stem cell research.
  • * Comprehensive risk assessment technologies are urgently needed for safe clinical translation.
  • * Addressing tumorigenicity and immunogenicity is essential for advancing stem cell therapies.