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Functional mitral regurgitation: are we treating the real target?
Giovanni Benfari1, Rajesh Dandale, Andrea Rossi
1aSection of Cardiology, Department of Medicine bSection of Cardiac Surgery, Department of Surgery, University of Verona cCardiology Division, Fondazione Salvatore Maugeri, IRCCS, Veruno, Italy.
Journal of Cardiovascular Medicine (Hagerstown, Md.)
|August 20, 2016
Summary
Functional mitral regurgitation, a valve issue with normal anatomy, stems from left ventricular remodeling. Percutaneous treatment may offer a better approach than surgery for this condition.
Area of Science:
- Cardiology
- Cardiovascular Surgery
Background:
- Functional mitral regurgitation (FMR) involves valve insufficiency despite normal mitral valve anatomy.
- It is caused by left ventricular remodeling, which impairs leaflet coaptation and is linked to ventricular dysfunction.
Purpose of the Study:
- To review the limitations of current surgical treatments for FMR.
- To explore percutaneous mitral valve repair as a potential alternative for FMR.
Main Methods:
- Review of existing literature on functional mitral regurgitation and its treatments.
- Discussion of surgical outcomes and confounding factors.
- Hypothesis regarding percutaneous intervention efficacy.
Main Results:
- Surgical treatment for FMR has yielded mixed results, with no clear survival benefit over medical therapy.
- Confounding factors in surgical studies may obscure the true benefits of addressing valve dysfunction.
- Percutaneous mitral valve repair presents a potentially more effective method for investigating FMR treatment.
Conclusions:
- Current surgical approaches for FMR have significant limitations and do not consistently improve survival.
- Percutaneous mitral valve repair, such as MitraClip, warrants further investigation as a promising therapeutic strategy for FMR.
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