Air pollution and ST-elevation myocardial infarction: A case-crossover study of the Belgian STEMI registry 2009-2013

Previous studies have shown that air pollution particulate matter (PM) is associated with an increased risk for myocardial infarction. The effects of air pollution on the risk of ST-elevation myocardial infarction (STEMI), in particular the role of gaseous air pollutants such as NO₂ and O₃ and the susceptibility of specific populations, are still under debate.

All patients entered in the Belgian prospective STEMI registry between 2009 and 2013 were included. Based on a validated spatial interpolation model from the Belgian Environment Agency, a national index was used to address the background level of air pollution exposure of Belgian population. A time-stratified and temperature-matched case-crossover analysis of the risk of STEMI was performed.

A total of 11,428 STEMI patients were included in the study. Each 10μg/m³ increase in PM10, PM2.5 and NO₂ was associated with an increased odds ratio (ORs) of STEMI of 1.026 (CI _95%: 1.005-1.048), 1.028 (CI _95%: 1.003-1.054) and 1.051 (CI _95%: 1.018-1.084), respectively. No effect of O₃ was found. STEMI was associated with PM10 exposure in patients ≥75y.o. (OR: 1.046, CI _95%: 1.002-1.092) and with NO₂ in patients ≤54y.o. (OR: 1.071, CI _95%: 1.010-1.136). No effect of air pollution on cardiac arrest or in-hospital STEMI mortality was found.

PM2.5 and NO₂ exposures incrementally increase the risk of STEMI. The risk related to PM appears to be greater in the elderly, while younger patients appear to be more susceptible to NO₂ exposure.