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Related Concept Videos

Transport Across the Golgi01:26

Transport Across the Golgi

6.5K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
6.5K
Golgi Matrix Proteins01:12

Golgi Matrix Proteins

2.5K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.5K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.3K
Golgi Apparatus01:09

Golgi Apparatus

22.6K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
22.6K
Golgi Apparatus01:49

Golgi Apparatus

107.1K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
107.1K
Golgi Apparatus01:09

Golgi Apparatus

4.7K
4.7K

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Related Experiment Video

Updated: Mar 16, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

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Stacking the odds for Golgi cisternal maturation.

Somya Mani1, Mukund Thattai1

  • 1Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.

Elife
|August 20, 2016
PubMed
Summary
This summary is machine-generated.

The Golgi apparatus can form through basic vesicle traffic rules, creating compartments that mature and recycle components. This finding supports the cisternal maturation model of the Golgi apparatus.

Keywords:
Boolean modelsGolgi apparatuscell biologycisternal maturationnonestatistical cell biologyvesicle traffic

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Related Experiment Videos

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Area of Science:

  • Cell biology
  • Systems biology
  • Biophysics

Background:

  • Eukaryotic organelle composition relies on molecular exchange via vesicle traffic.
  • Understanding the minimal requirements for organelle biogenesis is a fundamental question in cell biology.

Purpose of the Study:

  • To determine the minimal set of cell-biological ingredients required for generating a Golgi apparatus.
  • To investigate if cisternal maturation is an emergent property of homeostatic vesicle traffic.

Main Methods:

  • Statistical sampling of tens of thousands of homeostatic vesicle traffic networks.
  • Modeling vesicle budding and fusion using realistic molecular rules.
  • Analyzing network properties to identify emergent organizational motifs.

Main Results:

  • A plurality of simulated networks exhibited chains of compartments undergoing creation, maturation, and dissipation.
  • Molecular recycling via retrograde vesicles was a key feature of these networks.
  • The observed motif closely matched the cisternal maturation model of the Golgi apparatus.

Conclusions:

  • Cisternal maturation is a robust consequence of vesicle traffic homeostasis, independent of specific molecular details or spatial arrangement.
  • The Golgi apparatus architecture may have been exapted for its role in secretion rather than being exclusively selected for it.