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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Related Experiment Video

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In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Fluorescence multispectral imaging-based diagnostic system for atherosclerosis.

Cassandra Su Lyn Ho1, Toshikatsu Horiuchi2, Hiroaki Taniguchi2

  • 1Department of Electronic Systems Engineering, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, 54100, Kuala Lumpur, Malaysia.

Biomedical Engineering Online
|August 21, 2016
PubMed
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Multispectral fluorescence imaging detects lipid differences in atherosclerotic arteries. This technique offers a new, viable method for diagnosing atherosclerosis by analyzing arterial wall fluorescence.

Keywords:
Abdominal aortaAtherosclerosisCoronary arteryMultispectral fluorescence imaging

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Area of Science:

  • Biomedical imaging
  • Cardiovascular diagnostics
  • Optical spectroscopy

Background:

  • Atherosclerotic arterial walls accumulate lipids, notably cholesterol, distinguishing them from healthy vessels.
  • This lipid-rich composition presents a potential target for diagnostic imaging techniques.

Purpose of the Study:

  • To investigate the utility of multispectral fluorescence imaging for atherosclerosis diagnosis.
  • To leverage differences in arterial wall composition for disease identification.

Main Methods:

  • Illumination of extracted arteries (rabbit aorta, human coronary artery) with 405 nm excitation light.
  • Acquisition of multispectral fluorescence images to capture spectral data.
  • Pathological examination and measurement of intima-media thickness in human coronary arteries.

Main Results:

  • Distinct fluorescence spectra were observed between atherosclerotic and normal arterial sites.
  • A ratio of fluorescence intensity differences at specific wavelengths enabled discrimination of atherosclerotic regions.
  • Significant correlation found between fluorescence intensity and arterial wall thickness.

Conclusions:

  • Multispectral fluorescence imaging provides both qualitative and quantitative assessment of atherosclerosis.
  • The technique demonstrates viability as a diagnostic tool for atherosclerosis.