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Antibacterial resistance patterns of pediatric community-acquired urinary infection: Overview

Capan Konca1,2, Mehmet Tekin2, Fatih Uckardes3

  • 1Division of Pediatric Intensive Care Unit, School of Medicine, Adiyaman University, Adiyaman, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 21, 2016
PubMed

Insights

Antibiotic resistance is high in pediatric urinary tract infections (UTIs). This study guides empirical antibiotic treatment by analyzing common uropathogens and their resistance patterns in children with UTIs.

Area of Science:

  • Pediatric infectious diseases
  • Clinical microbiology
  • Antimicrobial stewardship

Background:

  • Urinary tract infections (UTIs) are a common pediatric illness.
  • Understanding uropathogen etiology and resistance is crucial for effective treatment.
  • Antibiotic resistance patterns necessitate updated treatment guidelines.

Purpose of the Study:

  • To develop a guide for empirical antibiotic treatment of community-acquired UTIs in children.
  • To investigate the etiology and antimicrobial resistance patterns of uropathogens.
  • To analyze epidemiological and clinical patient characteristics.

Main Methods:

  • 158 children with positive urine cultures were analyzed.
  • Antibiotic susceptibility testing was performed using Vitek 2 Compact.
  • 28 commonly used antimicrobials were tested against isolated uropathogens.

Main Results:

  • Escherichia coli (60.1%) and Klebsiella spp. (16.5%) were the most frequent uropathogens.
  • High resistance rates were observed for ampicillin/sulbactam (60.1%) and trimethoprim/sulfamethoxazole (44.2%).
  • Low resistance was noted for cefepime (8.7%), ertapenem (4.6%), norfloxacin (1.3%), and meropenem (0.7%). Amikacin showed no resistance.

Conclusions:

  • Pediatric UTIs exhibit significant antibiotic resistance.
  • Uropathogen resistance varies geographically and temporally, requiring periodic analysis.
  • Regular monitoring of antibiotic susceptibility trends is essential for appropriate UTI treatment regimens.
Abstract

Keywords:
antibiotic resistancechildurinary tract infectionuropathogen

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