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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Mar 16, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Dermatofibrosarcoma Protuberans.

Jeffrey Reha¹, Steven C Katz²

¹Department of Surgery, Roger Williams Medical Center, 825 Chalkstone Avenue, Prior 4, Providence, RI 02908, USA.

The Surgical Clinics of North America

|August 21, 2016

Summary

This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Effective management of this soft tissue sarcoma involves aggressive surgery and potentially targeted therapies for advanced cases.

Keywords:

DFSP Dermal sarcoma Dermatofibrosarcoma Soft tissue sarcoma Tyrosine kinase inhibitor

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Area of Science:

Oncology
Dermatology
Surgical Pathology

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare superficial soft tissue sarcoma.
Its rarity limits large-scale prospective research, necessitating a high index of clinical suspicion for diagnosis.
Understanding DFSP's biology and infiltrative growth is crucial for effective management.

Purpose of the Study:

To outline the diagnostic and management strategies for Dermatofibrosarcoma protuberans.
To highlight the importance of surgical resection and molecularly targeted therapies.
To emphasize the need for long-term follow-up in DFSP patients.

Main Methods:

Review of clinical presentation and diagnostic challenges.
Analysis of treatment modalities including surgical resection and radiotherapy.
Evaluation of molecular pathogenesis and targeted therapies like tyrosine kinase inhibitors.

Main Results:

DFSP is characterized by local recurrence and a low risk of dissemination.
Aggressive surgical resection with wide negative margins is the cornerstone of treatment.
Tyrosine kinase inhibitors offer a therapeutic option for advanced or metastatic DFSP.

Conclusions:

Effective DFSP management hinges on early diagnosis, aggressive surgical intervention, and consideration of adjuvant therapies.
Molecular insights have paved the way for targeted treatments in advanced disease.
Long-term surveillance is essential for patients diagnosed with DFSP.