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Mandibular Advancement Splints.

Ahmad A Bamagoos1, Kate Sutherland2, Peter A Cistulli2

  • 1Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Reserve Road, St Leonards, New South Wales 2065, Australia; Sleep Group, Charles Perkins Centre, Northern Clinical School, University of Sydney, Johns Hopkins Drive, Camperdown, New South Wales 2050, Australia; Department of Physiology, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Sleep Medicine Clinics
|August 21, 2016
PubMed
Summary
This summary is machine-generated.

Mandibular advancement splints (MAS) show better patient adherence than CPAP for sleep apnea. Predicting individual responses to MAS is key for effective treatment selection.

Keywords:
Mandibular advancement splintObstructive sleep apnea treatmentOral appliance

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Area of Science:

  • Sleep Medicine
  • Respiratory Medicine
  • Dental Sleep Medicine

Background:

  • Continuous positive airway pressure (CPAP) is effective for obstructive sleep apnea (OSA) but has low adherence.
  • Mandibular advancement splints (MAS) offer an alternative with higher patient preference and adherence.
  • The efficacy of MAS and CPAP on general health, cognition, and quality of life appears comparable.

Purpose of the Study:

  • To address the challenge of interindividual variability in MAS treatment response.
  • To explore phenotyping strategies for predicting patient response to MAS.
  • To improve patient selection for MAS therapy in clinical practice.

Main Methods:

  • Review of existing literature on MAS and CPAP efficacy and adherence.
  • Analysis of factors contributing to variable responses to MAS.
  • Discussion of proposed prediction tools and phenotyping approaches for MAS responders.

Main Results:

  • MAS demonstrates superior patient adherence and preference compared to CPAP.
  • Both MAS and CPAP yield similar outcomes in general health, cognitive function, and quality of life.
  • Interindividual variability in response is a significant barrier to widespread MAS implementation.

Conclusions:

  • Despite lower efficacy in reducing respiratory events, MAS is a viable alternative to CPAP due to better patient acceptance.
  • Phenotyping OSA patients is crucial for developing predictive models to optimize MAS treatment selection.
  • Further research into predictive tools can enhance the clinical utility of MAS for obstructive sleep apnea.