Related Experiment Video
Updated: Mar 16, 2026

Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
Published on: June 7, 2024
Measured body composition and geometrical data of four "virtual family" members for thermoregulatory modeling
Xiaojiang Xu1, Timothy P Rioux2, Tynan MacLeod2
1US Army Research Institute of Environmental Medicine, Biophysics and Biomedical Modeling Division, 10 General Greene Avenue, Natick, MA, 01760, USA. xiaojiang.xu.civ@mail.mil.
Abstract:
The purpose of this paper is to develop a database of tissue composition, distribution, volume, surface area, and skin thickness from anatomically correct human models, the virtual family. These models were based on high-resolution magnetic resonance imaging (MRI) of human volunteers, including two adults (male and female) and two children (boy and girl). In the segmented image dataset, each voxel is associated with a label which refers to a tissue type that occupies up that specific cubic millimeter of the body. The tissue volume was calculated from the number of the voxels with the same label. Volumes of 24 organs in body and volumes of 7 tissues in 10 specific body regions were calculated. Surface area was calculated from the collection of voxels that are touching the exterior air. Skin thicknesses were estimated from its volume and surface area. The differences between the calculated and original masses were about 3 % or less for tissues or organs that are important to thermoregulatory modeling, e.g., muscle, skin, and fat. This accurate database of body tissue distributions and geometry is essential for the development of human thermoregulatory models. Data derived from medical imaging provide new effective tools to enhance thermal physiology research and gain deeper insight into the mechanisms of how the human body maintains heat balance.
More Related Videos
Related Concept Videos
Clearance Models: Physiological Models
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
Body Water Content and Fluid Compartments
Thermoregulation
Assessing Body Temperature - Temporal Artery
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's...
Assessing Body Temperature - Oral
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
Model Approaches for Pharmacokinetic Data: Physiological Models

