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Almond supplementation reduces serum uric acid in coronary artery disease patients: a randomized controlled trial

Humaira Jamshed1, Anwar-Ul-Hassan Gilani2,3, Fateh Ali Tipoo Sultan4

  • 1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

Nutrition Journal
|August 21, 2016
PubMed

Insights

Daily almond consumption significantly lowers serum uric acid (UA) in patients with coronary artery disease (CAD). This dietary intervention may help prevent kidney and vascular damage associated with high UA levels.

Area of Science:

  • Cardiology
  • Nephrology
  • Nutritional Science

Background:

  • Elevated serum uric acid (UA) is a marker for renal insufficiency and an independent prognostic indicator for morbidity in coronary artery disease (CAD).
  • High UA levels pose significant health risks, necessitating effective management strategies in CAD patients.

Purpose of the Study:

  • To investigate the effect of daily almond consumption on serum UA levels in patients diagnosed with CAD.
  • To compare the impact of Pakistani almonds (PA) and American almonds (AA) on UA reduction.

Main Methods:

  • A randomized controlled clinical trial involving 150 CAD patients, divided into three groups: no-intervention (NI), Pakistani almonds (PA), and American almonds (AA).
  • Participants consumed 10g of almonds daily (soaked overnight, eaten before breakfast) for 12 weeks, with follow-ups at weeks 6 and 12.
  • Serum UA concentrations, blood pressure, and body weight were monitored throughout the study.

Main Results:

  • Almond supplementation significantly reduced serum UA levels (p < 0.05) in both PA and AA groups compared to the NI group.
  • At week 6, UA concentrations decreased by 13-16% in the almond groups; by week 12, the reduction ranged from 14-18%.
  • Systolic and diastolic blood pressure, as well as body weight, remained stable across all groups.

Conclusions:

  • Daily intake of 10g almonds, consumed before breakfast, effectively reduces serum UA in patients with CAD.
  • Preventing hyperuricemia through dietary almonds may offer protection against kidney and vascular damage.
  • Extrapolating these findings suggests broader health benefits of dietary almonds for the general population.
Abstract

Keywords:
Coronary artery diseaseHyperuricemiaLow doseNutsSoaked almonds

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