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Published on: July 19, 2024
An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer
Cheng S Jin1, Hironobu Wada2, Takashi Anayama2
1Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada. Institute of Biomaterial and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Princess Margaret Cancer Centre and TECHNA Institute, University Health Network, Toronto, Ontario, Canada.
Porphysome nanoparticles enable fluorescence-guided photothermal therapy (PTT) for early-stage lung cancer. This minimally invasive approach shows promise for selective tumor ablation in preclinical models, offering a new therapeutic option.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Early-stage peripheral lung cancer requires effective, minimally invasive treatments.
- Current nonsurgical options have limitations and complications.
- Novel therapeutic strategies are needed for improved patient outcomes.
Purpose of the Study:
- To develop and evaluate porphysome nanoparticle-enabled fluorescence-guided transbronchial photothermal therapy (PTT) for peripheral lung cancer.
- To assess the efficacy and safety of this novel platform in preclinical models.
Main Methods:
- Systemic administration of porphysomes in mouse and rabbit models with human lung cancer xenografts.
- In vivo fluorescence imaging using a prototype bronchoscope for tumor visualization.
- Transbronchial PTT guided by fluorescence and performed with a clinical diffuser fiber.
Main Results:
- Porphysomes accumulated in lung tumors, providing enhanced disease-to-normal tissue contrast.
- Real-time fluorescence imaging guided transbronchial PTT.
- Significant enhancement of PTT efficacy and selective tumor ablation observed in rabbits.
Conclusions:
- Porphysome nanoparticle-based fluorescence-guided transbronchial PTT is a viable minimally invasive therapeutic strategy for peripheral lung cancer.
- The platform demonstrates potential for clinical translation in treating early-stage lung cancer.
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