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Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Clozapine-induced dysphagia with secondary substantial weight loss
Mugtaba Osman1, Vekneswaran Devadas1
1Department of Psychiatry, Letterkenny General Hospital, Letterkenny, Ireland.
Abstract:
Dysphagia is listed as a 'rare' side effect following clozapine treatment. In this case report, we describe how significant clozapine-induced dysphagia has led to significant reduction of nutritional intake with subsequent substantial weight loss. An 18-year-old single man with an established diagnosis of treatment-resistant paranoid schizophrenia recovered well on a therapeutic dose of clozapine. However, he was noted to lose weight significantly (up to 20% of his original weight) as the dose was uptitrated. This was brought about by development of dysphagia, likely to be due to clozapine. Addition of nutritional supplementary liquids and initiation of a modified behavioural dietary/swallowing programme, while repeatedly mastering the Mendelsohn manoeuvre technique, alleviated the swallowing difficulties and restored his weight.
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